Adjunct Professor
Zee Upton
This person does not currently hold a position at QUT.
Personal details
Research field
Medical Biotechnology, Biochemistry and Cell Biology
Field of Research code, Australian and New Zealand Standard Research Classification (ANZSRC), 2008
Qualifications
- Ph.d (University of Adelaide)
Professional memberships and associations
- Member of Australian Society of Biochemistry and Molecular Biology
- Member of Women in Technology
- Member of International Society for IGF Research
- Member of Australian Society for Medical Research
- Member of the Australian Wound Management Association
- Member of Australasian Wound and Tissue Repair Society
Publications
- Parker, T., Sampson, D., Broszczak, D., Chng, Y., Carter, S., Leavesley, D., Parker, T. & Upton, Z. (2012). A fragment of the LG3 peptide of endorepellin is present in the urine of physically active mining workers: A potential marker of physical activity. PLoS One, 7(3), 1–12. https://eprints.qut.edu.au/48744
- Fernandez, M., Upton, Z., Edwards, H., Finlayson, K. & Shooter, G. (2012). Elevated uric acid correlates with wound severity. International Wound Journal, 9(2), 139–149. https://eprints.qut.edu.au/56560
- Upton, Z., Wallace, H., Shooter, G., Van Lonkhuyzen, D., Yeoh-Ellerton, S., Rayment, E., Fleming, J., Broszczak, D., Queen, D., Sibbald, G., Leavesley, D. & Stacey, M. (2011). Human pilot studies reveal the potential of a vitronectin: Growth factor complex as a treatment for chronic wounds. International Wound Journal, 8(5), 522–532. https://eprints.qut.edu.au/52592
- Kashyap, A., Hollier, B., Manton, K., Satyamoorthy, K., Leavesley, D. & Upton, Z. (2011). Insulin-like growth factor-I:Vitronectin complex-induced changes in gene expression effect breast cell survival and migration. Endocrinology, 152(4), 1388–1401. https://eprints.qut.edu.au/40398
- Xie, Y., Upton, Z., Richards, S., Rizzi, S. & Leavesley, D. (2011). Hyaluronic acid: Evaluation as a potential delivery vehicle for vitronectin: growth factor complexes in wound healing applications. Journal of Controlled Release, 153(3), 225–232. https://eprints.qut.edu.au/46400
- Xie, Y., Rizzi, S., Dawson, R., Lynam, E., Richards, S., Leavesley, D. & Upton, Z. (2010). Development of a three-dimensional human skin equivalent wound model for investigating novel wound healing therapies. Tissue Engineering, Part C: Methods, 16(5), 1111–1123. https://eprints.qut.edu.au/39201
- Kricker, J., Hyde, C., Van Lonkhuyzen, D., Hollier, B., Shooter, G., Leavesley, D., Herington, A. & Upton, Z. (2010). Mechanistic investigations into interactions between IGF-I and IGFBPs and their impact on facilitating cell migration on vitronectin. Growth Factors, 28(5), 359–369. https://eprints.qut.edu.au/39214
- Bott, K., Upton, Z., Schrobback, K., Ehrbar, M., Hubbell, J., Lutolf, M. & Rizzi, S. (2010). The effect of matrix characteristics on fibroblast proliferation in 3D gels. Biomaterials, 31(32), 8454–8464. https://eprints.qut.edu.au/43302
- Hollier, B., Kricker, J., Van Lonkhuyzen, D., Leavesley, D. & Upton, Z. (2008). Substrate-Bound Insulin-Like Growth Factor (IGF)-I-IGF Binding Protein-Vitronectin-Stimulated Breast Cell Migration Is Enhanced by Coactivation of the Phosphatidylinositide 3-Kinase/AKT Pathway by v-Integrins and the IGF-I Receptor. Endocrinology, 149(3), 1075–1090. https://eprints.qut.edu.au/13685
- Upton, Z., Cuttle, L., Noble, A., Kempf, M., Topping, G., Malda, J., Xie, Y., Mill, J., Harkin, D., Kravchuk, O., Leavesley, D. & Kimble, R. (2008). Vitronectin : Growth Factor Complexes Hold Potential as a Wound Therapy Approach. Journal of Investigative Dermatology, 128, 1535–1544. https://eprints.qut.edu.au/13019
QUT ePrints
For more publications by Zee, explore their research in QUT ePrints (our digital repository).
Awards
- Type
- Visiting Professorships/Fellowships
- Reference year
- 2006
- Details
- I was awarded an inaugural Smart State Senior Fellowship in 2006. This prestigious 3 year Fellowship awarded by the Queensland State Government (only 3 have been awarded thus far) facilitated my return to full-time research in July 2006 and is enabling me to conduct research on "An interdisciplinary approach towards smart wound healing solutions". The State Government provides $100K funding a year for three years and this matched with $50K a year each from QUT and the industry partner, Tissue Therapies Limited.
Selected research projects
- Title
- Composite Biomaterials for Modulation of Dermal Fibroblast Function
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- DP0877988
- Start year
- 2008
- Keywords
- Biomaterial; Hydrogel; Silicone; Fibroblast; Stratum Corneum
- Title
- Development and Pre-Clinical Evaluation of a Silicone Dressing for Scar Remediation
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 497267
- Start year
- 2008
- Keywords
- Silicones; Hypertropic Scarring; Keloid Scarring; Tissue Regeneration
- Title
- Development and Pre-clinical Evaluation of a Novel Wound Dressing Treatment for Chronic Ulcers
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 497266
- Start year
- 2008
- Keywords
- Skin; Wound Healing; Venous Leg Ulcers; Tissue Regeneration; Matrix Metalloproteinase; Bisphosphonate
- Title
- Molecularly Engineered Cell-instructive Hydrogels for Enhanced Tissue Regeneration
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- DP0877992
- Start year
- 2008
- Keywords
- Wound Healing; Insulin Like Growth Factor; Vitronectin; Extracellular Matrix; Biomaterial; Hydrogel
- Title
- Improved ex-vivo culture of keratinocytes for clinical applications
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 553028
- Start year
- 2009
- Keywords
- Clinical cell culture; Feeder-cell free; Burns; Wounds; Clinical Grafts
- Title
- Innovations in Diabetic Foot Ulcer (DFU) Wound Care
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 1048385
- Start year
- 2013
- Keywords
- biotechnology; stem cell therapy; ulceration; biomaterials; wound healing
Projects listed above are funded by Australian Competitive Grants. Projects funded from other sources are not listed due to confidentiality agreements.
Supervision
Completed supervisions (Doctorate)
- In Vitro Functional Characterisation of IGF-I:VN-induced Breast Cancer Progression (2013)
- Investigating epidermogenesis in a human skin equivalent model (2013)
- Pre-clinical evaluation of amphiphilic silicone oligomers for scar remediation (2011)
- A longitudinal assessment of chronic wound fluid to detect biochemical indicators of healing (2010)
- In Vitro Cultivation of Adult Human Chondrocytes: Importance of Culture System, Oxygen and Zonal Differences (2010)
- Ex Vivo Investigation of Novel Wound Healing Therapies and Development of a 3-D Human Skin Equivalent Wound Model (2009)
- Modelling of Some Biological Materials using Continuum Mechanics (2009)
- IGF: VN Complexes and their Role in Breast Cell migration (2008)
- Improved Strategies for the Cultivation of Human Limbal Epithelial (HLE) Grafts (2008)
- In vitro examination of vitronectin, insulin-like growth factor, insulin-like growth factor binding protein complexes as treatments to accelerate the healing of diabetic ulcers (2008)