
Associate Professor Travis Klein
Science and Engineering Faculty,Chemistry, Physics, Mechanical Engineering,
Biomedical Engineering and Medical Physics
Personal details
- Name
- Associate Professor Travis Klein
- Position(s)
- IHBI Theme Leader - Injury Prevention and Trauma Management
Science and Engineering Faculty,
Chemistry, Physics, Mechanical Engineering,
Biomedical Engineering and Medical Physics - Associate Professor
Science and Engineering Faculty,
Chemistry, Physics, Mechanical Engineering,
Biomedical Engineering and Medical Physics - IHBI Membership
Institute of Health Biomedical Innovation (IHBI),
IHBI Science and Engineering Projects,
IHBI Chem Physics Mech Engineering - IPTM - Discipline *
- Biomedical Engineering, Clinical Sciences, Biochemistry and Cell Biology
- Phone
- +61 7 3138 6142
- Fax
- +61 7 3138 6030
- t2.klein@qut.edu.au
- Location
- View location details (QUT staff and student access only)
- Identifiers and profiles
-
- Qualifications
-
PhD (Bioengineering) (University of California)
- Professional memberships
and associations - Keywords
-
cartilage, biofabrication, osteoarthritis, regenerative medicine, stem cells, tissue engineering, mechanobiology, biomaterials
Biography
Associate Professor Travis Klein heads the Cartilage Regeneration Laboratory (CRL) and the Injury Prevention and Trauma Management Theme at the Institute of Health and Biomedical Innovation. He is also the Biomedical Engineering and Medical Physics Discipline Leader in the School of Chemistry, Physics, and Mechanical Engineering, and the Deputy Director of the Australian Research Council Training Centre in Additive Biomanufacturing. Travis’ ultimate aim is to help develop long-term regenerative therapies for treating cartilage defects, including osteoarthritis. To help understand chondrogenesis and joint pathologies, and engineer functional tissues, his group is developing:
- model systems using human cells
- functionalised biomaterials
- biofabrication approaches
- mechanical stimulation technologies
In addition, the CRL works towards advancing imaging technologies for monitoring changes in native and tissue-engineered cartilage. One particular area of interest has been in understanding the differences between chondrocytes and extracellular matrix of different depth zones, and recapitulating these in vitro. Google Scholar link: http://scholar.google.com.au/citations?user=RYS5blIAAAAJ
Publications
- Meinert CC, Schrobback K, Hutmacher D, Klein TJ, (2017) A novel bioreactor system for biaxial mechanical loading enhances the properties of tissue-engineered human cartilage, Scientific Reports p1-14
- Bas O, Juan Pardo E, Meinert CC, Baldwin JG, Bray LJ, Wellard RM, Klein TJ, Hutmacher D, (2017) Biofabricated soft network composites for cartilage tissue engineering, Biofabrication p1-15
- Yue K, Li X, Schrobback K, Sheikhi A, Annabi N, Leijten J, Zhang W, Zhang Y, Hutmacher D, Klein TJ, Khademhosseini A, (2017) Structural analysis of photocrosslinkable methacryloyl-modified protein derivatives, Biomaterials p163-171
- Meinert C, Schrobback K, Levett PA, Lutton CJ, Sah RL, Klein TJ, (2017) Tailoring hydrogel surface properties to modulate cellular response to shear loading, Acta Biomaterialia p105-117
- Bartnikowski M, Akkineni A, Gelinsky M, Woodruff MA, Klein TJ, (2016) A hydrogel model incorporating 3D-plotted hydroxyapatite for osteochondral tissue engineering, Materials p1-17
- Loessner D, Meinert CC, Kammerer E, Martine LC, Yue K, Levett PA, Klein TJ, Melchels FP, Khademhosseini A, Hutmacher D, (2016) Functionalization, preparation and use of cell-laden gelatin methacryloyl-based hydrogels as modular tissue culture platforms, Nature Protocols p727-746
- Bartnikowski M, Bartnikowski NJ, Woodruff MA, Schrobback K, Klein TJ, (2015) Protective effects of reactive functional groups on chondrocytes in photocrosslinkable hydrogel systems, Acta Biomaterialia p66-76
- Levett PA, Melchels FP, Schrobback K, Hutmacher D, Malda J, Klein TJ, (2014) A biomimetic extracellular matrix for cartilage tissue engineering centered on photocurable gelatin, hyaluronic acid and chondroitin sulfate, Acta Biomaterialia p214-223
- Jeon J, Schrobback K, Meinert C, Sremek V, Hutmacher D, Klein TJ, (2013) Effect of preculture and loading on expression of matrix molecules, matrix metalloproteinases, and cytokines by expanded osteoarthritic chondrocytes, Arthritis and Rheumatism p2356-2367
- Schuurman W, Levett PA, Pot MW, Van Weeren P, Dhert WJ, Hutmacher D, Melchels FP, Klein TJ, Malda J, (2013) Gelatin-methacrylamide hydrogels as potential biomaterials for fabrication of tissue-engineered cartilage constructs, Macromolecular Bioscience p551-561
For more publications by this staff member, visit QUT ePrints, the University's research repository.
Awards
Awards and recognition
- Type
- Recipient of a Nationally Competitive Research Fellowship
- Reference year
- 2011
- Details
- Fellowship Type: ARC Principal Research Fellowship Project Title: Regenerating articular cartilage with smart hydrogels and fabrication technologies External Reference : FT110100166 Years Awarded: 2011 - 2015 Total Funding Awarded: $639,288
- Type
- Recipient of a Nationally Competitive Research Fellowship
- Reference year
- 2008
- Details
- DP0878365- APD (2008-2010) Australian Postdoctoral Fellowship (APD) "Engineering Articular Cartilage with Zonal Structure and Function"
Research projects
Grants and projects (Category 1: Australian Competitive Grants only)
- Title
- A Novel Multiscale Model to Investigate Mechanical Properties of Cartilage
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- DP180103009
- Start year
- 2018
- Keywords
- Title
- ARC Training Centre in Additive Biomanufacturing
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- IC160100026
- Start year
- 2017
- Keywords
- Title
- Coupling an injectable gel and MSC microtissues to enhance cartilage repair
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 1083857
- Start year
- 2015
- Keywords
- cartilage; regenerative medicine; stem cell therapy; biomedical engineering; biomaterials
- Title
- Bioactivated hierarchical hydrogels as zonal implants for articular cartilage regeneration
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 1067108
- Start year
- 2014
- Keywords
- Cartilage Damage; Cell Differentiation; Chondrocytes; Osteoarthritis; Stem Cells
- Title
- MAPK/ERK pathway in osteoarthritis
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 1032738
- Start year
- 2012
- Keywords
- osteoarthritis; pathogenesis; cell signalling; kinases; animal model
- Title
- Regenerating articular cartilage with smart hydrogels and fabrication technologies
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- FT110100166
- Start year
- 2012
- Keywords
- Cartilage; Regenerative Medicine; Biofabrication
- Title
- Interplay Between Mechanical and Biological Microenvironments in Chondrocyte Function: Towards an Understanding of Cartilage Pathology
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- DP110103543
- Start year
- 2011
- Keywords
- Cartilage; Arthritis; Biomaterials; Lubrication; Hydrogel
- Title
- Engineering Articular Cartilage with Zonal Structure and Function
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- DP0878365
- Start year
- 2008
- Keywords
- Arthritis; Cartilage; Tissue Engineering; Regenerative Medicine; Scaffold; Stem Cells;
Supervision
Completed supervisions (Doctorate)
- Photocrosslinkable Hydrogels for Cartilage Tissue Engineering (2016)
- Design and Characterisation of Scaffolds for Osteochondral Regeneration (2015)
- Environments for Zonal Cartilage Tissue Engineering (2015)
- Development of Zonal Cartilage Constructs: Effects of Chondrocyte Subpopulation, Compressive Stimulation, and Culture Models (2012)
- In Vitro Cultivation of Adult Human Chondrocytes: Importance of Culture System, Oxygen and Zonal Differences (2010)