- Dr Trudi Collet
- Senior Lecturer in Pharmacy
Faculty of Health,
School - Clinical Sciences
- IHBI Membership
Institute of Health Biomedical Innovation (IHBI),
IHBI Health Projects,
IHBI Clinical Sciences - CDA
- Discipline *
- Biochemistry and Cell Biology, Microbiology, Other Biological Sciences
- +61 7 3138 1900
- View location details (QUT staff and student access only)
- Identifiers and profiles
Ph.D (Queensland University of Technology)
- Professional memberships
- Leader – Innovative Medicines Group (IMG)
- Professional Memberships:
- Australian Wound Management Association Inc.
- Australasian Wound & Tissue Repair Society
- Australasian Pharmaceutical Science Association
Research theme: Chronic Disease and Ageing
Research discipline: Clinical Sciences
Research Program: Infectious Diseases
Research area: Australian native plants: novel therapeutics for common global infections and diseases
Chronic wounds, often associated with venous and arterial ulcers, diabetes and pressure sores, is an area of major concern as the on-going and in-direct costs are substantial, reaching far beyond the costs of the physician and hospitalisation. Current figures indicate that approximately six million people suffer from chronic wounds worldwide. In Australia, the prevalence of chronic wounds (200,000 – 600,000), is estimated to be 7-8 times higher within the indigenous population compared with nonindigenous Australians. Wound healing or wound repair is an intricate and complex process that requires the synergistic interaction of numerous tissues and cell lineages. Thus, the innate wound healing process acts to moderate tissue damage and provide sufficient oxygenation and nutrition to facilitate restoration, function and anatomical continuity of the affected area. Skin replacement, wound dressings and physical therapies are the three common approaches used to promote the healing of chronic wounds, whilst exposure to hyperbaric oxygen and application of topical growth factors are occasionally utilised. Unfortunately, such approaches are expensive, ineffective or problematic due to unwanted side effects. Pharmacological therapies have been developed to address these treatment insufficiencies, however, the availability of drugs capable of promoting the wound repair process still remains limited. Aboriginal bush medicine has been used for thousands of years and thus, the wound healing ability of various herbal plants is well recognised amongst native Australians. Recent studies have demonstrated that several Australian plant species used for medicinal purposes by the indigenous population do in fact produce biologically active extracts and compounds. Hence, traditional herbal plants may provide avenues for promoting the wound healing process and improving patient outcomes with a concomitant reduction in associated treatment cost. A scientific approach that examines the pharmacological efficacy of natural medicines reported to have an effect on wound healing is necessary to validate traditional accounts.
- Complementary herbal medicines and their bactericidal, bacteriostatic and anti-inflammatory wound healing potential
The investigation of medicinal plants for their wound healing potential is an emergent and rapidly expanding field which is not limited to Aboriginal bush medicine. “Classic” natural medicines such as aloe vera, calendula and hypericum for example are reported to have wound healing properties. Also of interest is Ayurveda, the traditional system of medicine in India, which is a holistic approach to healing that evolved more than 3,000 years ago. Ayurvedic texts mention more than 1200 disease states and show that management of these diseases can be accomplished with the use of medicinal plants (90%), minerals, metals or ores (5%) and animal and marine products (5%). Wound healing and cognate treatments, highlighted in many Ayurvedic texts are reported for their wound healing activity, although, like Chinese, Aboriginal and natural herbal medicines, the activity of various medicinal plants have not been scientifically validated.
Areas of Expertise
- wound healing
- medical biotechnology
- protein chemistry
- complementary medicines
- molecular microbiology
- Infectious diseases
Selected research projects
- The in vitro wound healing effects of Aboriginal medicinal plants.
- Identification of bioactive compounds in Aboriginal medicinal plants and their effects on wound healing.
- The bactericidal, bacteriostatic and anti-inflammatory wound healing potential of Ayurvedic medicinal plants.
- Collet T, Huygens F, Radford-Smith G, (2008) Identification of novel serological markers for the diagnosis of inflammatory bowel disease, Journal of Gastroenterology and Hepatology, Volume 23, Issue Supplement 4: Abstracts of the Australian Gastroenterology Week 2008 pA215
- Armitage TA, Macnaughton TB, Debattista J, Walsh TP, Timms P, (2006) Identification of novel markers for acute and chronic Chlamydia trachomatis infections, Proceedings of the 11th International Symposium on Human Chlamydial Infections p603-606
- Timms P, Armitage TA, Macnaughton TB, Walsh TP, (2007) Patent: (WO/2007/030879) Diagnostic markers and uses therefor - PCT/AU2006/001346
- Treloar SA, Zhao Z, Collet T, Duffy DL, Wicks J, O'Connor DT, Martin NG, Montgomery GW, (2005) Association between polymorphisms in the progesterone receptor gene and endometriosis, Molecular Human Reproduction: basic science of reproductive medicine p641-647
- Collet TA, Macnaughton TB, Walsh TP, Debattista J, Timms P, (2011) Identification of novel markers for uncomplicated lower genital tract infections and upper genital tract pathology due to Chlamydia trachomatis, International Journal of Infectious Diseases pe257-e266