Personal details

Name
Associate Professor Michael Doran
Position(s)
Associate Professor
Faculty of Health,
School - Biomedical Sciences
IHBI Membership
Institute of Health Biomedical Innovation (IHBI),
IHBI Health Projects,
IHBI Biomedical Sciences - CDA
Discipline *
Biochemistry and Cell Biology, Microbiology, Oncology and Carcinogenesis
Phone
+61 7 3443 7348
Email
Location
View location details (QUT staff and student access only)
Identifiers and profiles
ORCID iD
Qualifications

PhD (University of New South Wales)

Professional memberships
and associations

Please see my laboratory’s webpage: http://mikedoranlab.com

* Field of Research code, Australian and New Zealand Standard Research Classification (ANZSRC), 2008

Biography

Please see my laboratory’s webpage: http://www.mikedoranlab.com

 

Training:

  • Bachelor of Science (Genetics) – The University of Alberta (Canada)
  • Bachelor of Engineering (Chemical) – The University of Alberta (Canada)
  • PhD (Biomedical Engineering) – The University of New South Wales (Australia)

Affiliations:

  • NHMRC Research Fellow 
  • Group Leader – Translational Research Institute
  • Associate Professor – School of Biomedical Sciences – Queensland University of Technology
  • Honorary Research Fellow – Mater Research Institute – University of Queensland
  • Honorary Associate Professor – Australian National Centre for the Public Awareness of Science – Australian National University

Research interests:

  • Bioreactor development for large-scale stem or stromal cell expansion.
  • Development of novel umbilical cord blood transplantation techniques.
  • Development of tissue engineering/stem cell strategies for cartilage defect repair.
  • Development of tissue engineering strategies for diabetic foot ulcer repair.
  • Design/development of micro-bioreactors for bone marrow stem cell niche recapitulation.
  • Development of platforms to study prostate and breast cancer bone metastasis.
  • General, including: (1) macroeconomics, (2) the use of multimedia in scientific communication, and (3) the evolution of academia as a business and the associated management challenges.
This information has been contributed by Associate Professor Michael Doran.

Teaching

UNDERGRADUATE TEACHING

  • As a PhD Candidate I tutored Biochemistry, and I was fortunate to have the opportunity to deliver some lectures in Biomechanics for the UNSW School of Engineering.
  • As a PostDoc at UQ I lectured into the Cell and Tissue Engineering Unit (4th year School of Engineering) in 2007, 2008, and 2009.  In 2008 I was Course Captain for this unit.
  • At QUT,  I coordinated and lectured LQB248 (Biomedical Skills II, Statistics and scientific communication) in 2013 and 2014.
  • At QUT, I coordinated and lectured LQB595 (Cellular Engineering) in 2015 and 2016.

POSTGRADUATE and DORAN LAB

  • Ms Ena Music (PhD Candidate – Supervised by Doran, Klein, and Lott). Ms Music is developing methods for cartilage defect repair using both MSC and articular chondrocytes.  She is conducting on-going evaluations in mouse models, with the intention of trialing her optimized technology in sheep in 2016.
  • Ms Eman Othman (PhD Candidate – Supervised by Doran, Clemments, and Chambers).  Ms Othman is studying prostate cancer bone metastasis.  She is utilising a 3D bone model that she has developed to allow her to both quantify prostate cancer cell interaction with the bone tissue(s), and as a platform to determine how bone-like tissue(s) influence prostate cancer cell drug sensitivity.
  • Mr Eric Franklin (PhD Candidate – Supervised by Doran and Thompson). Mr Franklin is working to understand the roles that bone marrow stromal cell populations, and/or hypoxia play in breast bone metastasis.
  • Ms Melissa Monterosso (PhD Candidate – Supervised by Doran, Lott and Williams).  Ms Monterosso is working on a prostate cancer bone marrow niche mimic (in vivo and in vitro).  Ms Monterosso has developed a novel xenograft platform which we hope will enable more efficient manipulation and propagation of challenging prostate cancer xenografts.
  • Dr James Palmer (Supervised by Doran).  Dr Palmer has developed elegant genetic inducible systems designed to enable cells used in cartilage repair therapies to secrete factors which will promote tissue repair. Using feedback systems, he has developed a microRNA based platform designed to mitigate MSC hypertrophy.
  • Ms Bianca Nowland (PhD Candidate – Supervised by Doran and Williams).  Using a novel method developed in our laboratory, Ms Nowland is humanising NSG mice with different bone marrow stromal cell populations.  This model will be utilised to study the influence of different human stromal populations on human HSC homing and engraftment, as well as prostate cancer cell homing and engraftment (metastatic tumour formation).
  • Dr Parisa Ghavani (MSc Candidate – Supervised by Doran and Klein).  Dr Ghavani is evaluating the use of donor (allogenic and xenogeneic) cartilage matrix to augment cell-based cartilage repair therapies.
This information has been contributed by Associate Professor Michael Doran.

Experience

CONFERENCE ORGANIZATION: In 2014 I chaired the first STEM CELL SYMPOSIUM at TRI.  This two-day event featured invited national and international speakers (https://www.tri.edu.au/event/2014-stem-cell-conference).   HIGH SCHOOL RESEARCH IMMERSION PROGRAMS:
In 2014 my laboratory hosted two very talented high school students (Catie and Isabelle).  Over a 1 week period these students learned general cell culture techniques, how specifically to grow bone marrow stem/stromal cells, how to differentiate these cells into either bone or fat cells, and how to seed bone cells onto scaffolds. This program was well received, and my team enjoyed the opportunity to share their skills.  This positive outcome motivated us to attempt to bring this experience to a wider group of high school students, and so we teamed up with Dr Peter Darben from the SPARQ-ED Program (Education Queensland and the TRI – http://www.di.uq.edu.au/sparqed-explained).
In 2015 we hosted 25 high school students from around Australian in a 1 week intensive research immersion course at the TRI (http://www.di.uq.edu.au/msc-project).  Again, students learned general cell culture techniques, how specifically to grow bone marrow stem/stromal cells, how to differentiate these cells into either bone or fat cells, and how to seed the bone cells onto scaffolds.  We thank Dr Peter Darben for this incredible opportunity and his gentle coaching.  The team got a kick out of working with the ambitious high school students, and this experience has motivated us to contribute to future SPARQ-ED programs. I’ve included comments from SPARQ-ED high school students below:

  • “Interactions with other students with the same interests -> self-explanatory. Learning to operate scientific equipment. Listening to experts talk because I found what they said extremely interesting” – Male Student
  • “I really enjoyed the physical lab work. It gave me great insight into research and helped me decide that I would like to go into research in the future” – Female Student
  • “The exposure to the labs and experience of what scientists do” – Female Student
  • “Understanding the concepts as a whole, and seeing all the elements some together when the 3D scaffold was seeded with cells” – Male Student
  • “All the practical activities were very rewarding because I did not know the procedures beforehand” – Male Student.
  • “I found the lab work rewarding as it was useful to my future and learnt many new techniques. I found the lectures useful as they will help me with school work” – Female Student
  • “The best parts of the program was the lab activities because I find it easier to understand the concepts” – Male Student
  • “I enjoyed the experience itself, however the most rewarding experience I had was developing new friendships” – Male Student
  • “I enjoyed the migration / wound healing experiment because we got to decide which drinks to use and it was therefore more like we were doing the experiment rather than just following instructions (which was fine) – it would be nice to have more experiments like that” – Female Student
  • “The people I met and the immersion into very hands-on work, We met many scientists that helped us understand what a career in research Science will look like” – Female Student
  • “Experience in professional lab. Advanced scientific topics not generally covered in school. Talking to working scientists” – Female Student
  • “The overall lab work and seminars were very rewarding as they showed the process real researchers undertake” – Male Student
  • “Preparing solutions by following procedures outlined in manual – procedures were clear and this gave a sense of independency. Seeing successful cell growth was rewarding J” – Female Student
  • “The migration and expansion assay were particularly rewarding. I understood these concepts the most and found the results very interesting. The application of this kind of research also was very interesting and could be related to on a practical level. It puts the work that is being done into perspective and is really very relevant. I also think the presentation will prove to be very rewarding, as it will be relevant and will therefore help students when writing EEI reports in class. Seeing the facilities was very rewarding and a great opportunity. This week has been great” – Female Student
  • “The lectures before each part of the project were very useful as they allowed me to understand and explain what I was doing” – Male Student
  • “Being able to see results, do real lab work” – Male Student
  • “I made a lot of friends and learnt many relevant scientific and cellular concepts” – Male Student
  • “The hands-on research experiments because I have never experiences research in an actual research facility. It gave me an insight on the work researchers do and the equipment they have available to them” – Female Student
  • “Laboratory work -> hands on approach, realistic experience of what to expect in a biomedical science career. Ability to view, engage with and use high-tech equipment. Friday lunch. Being able to discuss with the tutors assisting and getting their insight on their careers, etc. being in the beautiful building J” – Female Student
  • “The 3D printing was interesting and showed a technology I hadn’t seen much of before. Plus insights into possible future applications. Also getting to apply techniques and use the equipment and machines available in the TRI and would never be seen in a school course” – Female Student
  • “I found the 3D printing particularly interesting, however the thing I found most rewarding as a whole was just being allowed to use the equipment, and gather an understanding of what happens in scientific research facilities” – Female Student
  • “Learning how to use the equipment in the lab and being able to see the upstairs working spaces. Also talking to all of the scientists about what they do and the university courses they completed to get where they are today” – Female Student
  • “Presenting at the end of the program -> needed us to coherently sum up and condense a lot of information and data, which improved understanding of concepts. As well as, of course, the lab work and talks about the topics and conducting routine lab work” – Female Student
  • “The socialising parts – where you had open conversations” – Male Student

VIDEOS (produced by Michael Kuhn (QUT))

GRANT COMMUNICATION

This information has been contributed by Associate Professor Michael Doran.

Publications


For more publications by this staff member, visit QUT ePrints, the University's research repository.

Research projects

Grants and projects (Category 1: Australian Competitive Grants only)

Title
Bridging the fields of cartilage, bone marrow and cancer research
Primary fund type
CAT 1 - Australian Competitive Grant
Project ID
1130013
Start year
2017
Keywords
Stem Cell Biology; Osteoarthritis; Prostate Cancer; Bone Marrow Transplantation; Biomedical Engineering
Title
The Microniche: A Novel In-vitro and In-vivo Prostate Cancer Model System
Primary fund type
CAT 1 - Australian Competitive Grant
Project ID
1108043
Start year
2016
Keywords
Prostate Cancer; Metastatic Cancer; Bone Marrow; Stem Cell Biology; Hormone-refractory Prostate Cancer
Title
Coupling an injectable gel and MSC microtissues to enhance cartilage repair
Primary fund type
CAT 1 - Australian Competitive Grant
Project ID
1083857
Start year
2015
Keywords
cartilage; regenerative medicine; stem cell therapy; biomedical engineering; biomaterials
Title
Engineering an Osteochondral Tissue for Cartilage Defect Repair
Primary fund type
CAT 1 - Australian Competitive Grant
Project ID
1060340
Start year
2014
Keywords
Biomedical Engineering; Stem Cells; Cartilage; Osteoarthritis; Tissue Engineering
Title
Mimicking the HSC Niche and Enabling HSC Self-renewal In Vitro
Primary fund type
CAT 1 - Australian Competitive Grant
Project ID
CA-APP1060928
Start year
2014
Keywords
Regenerative Medicine; Stem Cells; Stem Cell Therapy; Haematopoietic Stem Cells; Haematopoiesis; Bone Marrow Stroma; Bone Marrow
Title
Engineering a High-Throughput Prostate Cancer Stem Cell Niche Mimic
Primary fund type
CAT 1 - Australian Competitive Grant
Project ID
NCG 3212
Start year
2013
Keywords
Bioengineering; Cancer; Stem Cells; Therapy
Title
Innovations in Diabetic Foot Ulcer (DFU) Wound Care
Primary fund type
CAT 1 - Australian Competitive Grant
Project ID
1048385
Start year
2013
Keywords
biotechnology; stem cell therapy; ulceration; biomaterials; wound healing
Title
Taking the Limp out of Cartilage Repair
Primary fund type
CAT 1 - Australian Competitive Grant
Project ID
631629
Start year
2010
Keywords
Biomedical Engineering; Catilage; Stem Cells; Regenerative Medicine