Professor Travis Klein
Faculty of Engineering,
School of Mech., Medical & Process Engineering
Biography
Professor Travis Klein is the leader of the Cartilage Regeneration Laboratory (CRL) at Queensland University of Technology (QUT). The ultimate aim of the CRL is to help develop long-term regenerative therapies for treating cartilage defects, including osteoarthritis. One particular area of interest has been in understanding the differences between chondrocytes and extracellular matrix of different depth zones, and recapitulating these in vitro. To help understand chondrogenesis and joint pathologies, and engineer functional tissues, Travis' group is developing:- functional biomaterials
- 3D cell culture systems
- biofabrication approaches
- mechanical stimulation technologies
Travis was the founding Director of the QUT Centre for Biomedical Technologies, which aims to deliver better health in our lifetime, by improving how we treat complex medical cases stemming from injuries, infection and age-related issues.
Google Scholar link: http://scholar.google.com.au/citations?user=RYS5blIAAAAJ
Personal details
Positions
- Professor
Faculty of Engineering,
School of Mech., Medical & Process Engineering
Keywords
cartilage, biofabrication, osteoarthritis, regenerative medicine, stem cells, tissue engineering, mechanobiology, biomaterials
Research field
Biomedical Engineering, Clinical Sciences, Biochemistry and Cell Biology
Field of Research code, Australian and New Zealand Standard Research Classification (ANZSRC), 2008
Qualifications
- PhD (Bioengineering) (University of California)
Professional memberships and associations
- Centre for Biomedical Technologies
- Australia-China Centre for Tissue Engineering and Regenerative Medicine
- ARC Training Centre for Cell and Tissue Engineering Technologies
- ARC Training Centre for Joint Biomechanics
- Australasian Society of Biomaterials and Tissue Engineering
- Tissue Engineering and Regenerative Medicine International Society
Teaching
Travis is the Unit Coordinator for EGH438 - Biomaterials, and ENN532 - Safety and Environmental Management.
He also is a lecturer in EGB121 - Engineering Mechanics, and EGB435 - Advanced Manufacturing.
Further, he supervises final year projects (EGH400).
Publications
Research outputs by year
- Weekes, A., Bartnikowski, N., Pinto, N., Jenkins, J., Meinert, C. & Klein, T. (2022). Biofabrication of small diameter tissue-engineered vascular grafts. Acta Biomaterialia, 138, 92–111. https://eprints.qut.edu.au/231330
- Steele, J., Moore, A., St-Pierre, J., McCullen, S., Gormley, A., Horgan, C., Black, C., Meinert, C., Klein, T., Saifzadeh, S., Steck, R., Ren, J., Woodruff, M. & Stevens, M. (2022). In vitro and in vivo investigation of a zonal microstructured scaffold for osteochondral defect repair. Biomaterials, 286. https://eprints.qut.edu.au/231989
- Forrestal, D., Allenby, M., Simpson, B., Klein, T. & Woodruff, M. (2022). Personalized Volumetric Tissue Generation by Enhancing Multiscale Mass Transport through 3D Printed Scaffolds in Perfused Bioreactors. Advanced Healthcare Materials, 11(24). https://eprints.qut.edu.au/233923
- Futrega, K., Robey, P., Klein, T., Crawford, R. & Doran, M. (2021). A single day of TGF-ß1 exposure activates chondrogenic and hypertrophic differentiation pathways in bone marrow-derived stromal cells. Communications Biology, 4. https://eprints.qut.edu.au/209587
- Lawson, T., Mäkelä, J., Klein, T., Snyder, B. & Grinstaff, M. (2021). Nanotechnology and Osteoarthritis. Part 2: Opportunities for advanced devices and therapeutics. Journal of Orthopaedic Research, 39(3), 473–484. https://eprints.qut.edu.au/206474
- Pahoff, S., Meinert, C., Bas, O., Nguyen, B., Klein, T. & Hutmacher, D. (2019). Effect of gelatin source and photoinitiator type on chondrocyte redifferentiation in gelatin methacryloyl-based tissue-engineered cartilage constructs. Journal of Materials Chemistry B, 7(10), 1761–1772. https://eprints.qut.edu.au/128675
- Meinert, C., Schrobback, K., Hutmacher, D. & Klein, T. (2017). A novel bioreactor system for biaxial mechanical loading enhances the properties of tissue-engineered human cartilage. Scientific Reports, 7, 1–14. https://eprints.qut.edu.au/115053
- Bas, O., Juan Pardo, E., Meinert, C., Baldwin, J., Bray, L., Wellard, R., Klein, T. & Hutmacher, D. (2017). Biofabricated soft network composites for cartilage tissue engineering. Biofabrication, 9(2), 1–15. https://eprints.qut.edu.au/107693
- Loessner, D., Meinert, C., Kammerer, E., Martine, L., Yue, K., Levett, P., Klein, T., Melchels, F., Khademhosseini, A. & Hutmacher, D. (2016). Functionalization, preparation and use of cell-laden gelatin methacryloyl-based hydrogels as modular tissue culture platforms. Nature Protocols, 11(4), 727–746. https://eprints.qut.edu.au/102207
- Levett, P., Melchels, F., Schrobback, K., Hutmacher, D., Malda, J. & Klein, T. (2014). A biomimetic extracellular matrix for cartilage tissue engineering centered on photocurable gelatin, hyaluronic acid and chondroitin sulfate. Acta Biomaterialia, 10(1), 214–223. https://eprints.qut.edu.au/64930
QUT ePrints
For more publications by Travis, explore their research in QUT ePrints (our digital repository).
Awards
- Type
- Recipient of a Nationally Competitive Research Fellowship
- Reference year
- 2011
- Details
- Fellowship Type: ARC Principal Research FellowshipProject Title: Regenerating articular cartilage with smart hydrogels and fabrication technologiesExternal Reference : FT110100166Years Awarded: 2011 - 2015Total Funding Awarded: $639,288
- Type
- Recipient of a Nationally Competitive Research Fellowship
- Reference year
- 2008
- Details
- DP0878365- APD (2008-2010)Australian Postdoctoral Fellowship (APD) "Engineering Articular Cartilage with Zonal Structure and Function"
Selected research projects
- Title
- ARC Industrial Transformation Training Centre for Joint Biomechanics
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- IC190100020
- Start year
- 2020
- Keywords
- Title
- ARC ITTC (CTET) for Cell and Tissue Engineering Technologies
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- IC190100026
- Start year
- 2019
- Keywords
- Title
- A Novel Multiscale Model to Investigate Mechanical Properties of Cartilage
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- DP180103009
- Start year
- 2018
- Keywords
- Title
- ARC Training Centre in Additive Biomanufacturing
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- IC160100026
- Start year
- 2017
- Keywords
- Title
- Coupling an injectable gel and MSC microtissues to enhance cartilage repair
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 1083857
- Start year
- 2015
- Keywords
- cartilage; regenerative medicine; stem cell therapy; biomedical engineering; biomaterials
- Title
- Bioactivated hierarchical hydrogels as zonal implants for articular cartilage regeneration
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 1067108
- Start year
- 2014
- Keywords
- Cartilage Damage; Cell Differentiation; Chondrocytes; Osteoarthritis; Stem Cells
- Title
- MAPK/ERK pathway in osteoarthritis
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 1032738
- Start year
- 2012
- Keywords
- osteoarthritis; pathogenesis; cell signalling; kinases; animal model
- Title
- Regenerating articular cartilage with smart hydrogels and fabrication technologies
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- FT110100166
- Start year
- 2012
- Keywords
- Cartilage; Regenerative Medicine; Biofabrication
- Title
- Interplay Between Mechanical and Biological Microenvironments in Chondrocyte Function: Towards an Understanding of Cartilage Pathology
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- DP110103543
- Start year
- 2011
- Keywords
- Cartilage; Arthritis; Biomaterials; Lubrication; Hydrogel
- Title
- Engineering Articular Cartilage with Zonal Structure and Function
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- DP0878365
- Start year
- 2008
- Keywords
- Arthritis; Cartilage; Tissue Engineering; Regenerative Medicine; Scaffold; Stem Cells
Projects listed above are funded by Australian Competitive Grants. Projects funded from other sources are not listed due to confidentiality agreements.
Supervision
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Completed supervisions (Doctorate)
- Gelatin-methacryloyl-chitosan (GelMA-CS) hydrogel: a novel orthopaedic bioadhesive (2023)
- Molecular dynamics of gelatin-based peptide systems (2023)
- Flow Control in Perfusion Bioreactors for Improved Cell Culture within Porous Tissue Scaffolds (2019)
- New Mechanical Indentation Framework for Functional Assessment of Articular Cartilage (2018)
- Hydrogels and Bioreactors for Cartilage Research and Functional Tissue Engineering (2017)
- Photocrosslinkable Hydrogels for Cartilage Tissue Engineering (2016)
- Design and Characterisation of Scaffolds for Osteochondral Regeneration (2015)
- Environments for Zonal Cartilage Tissue Engineering (2015)
- Development of Zonal Cartilage Constructs: Effects of Chondrocyte Subpopulation, Compressive Stimulation, and Culture Models (2012)
- In Vitro Cultivation of Adult Human Chondrocytes: Importance of Culture System, Oxygen and Zonal Differences (2010)