- Professor Kenneth Beagley
- Professor of Immunology
Faculty of Health,
School of Biomedical Sciences
- IHBI Membership
Institute of Health Biomedical Innovation (IHBI),
IHBI Health Projects,
IHBI Biomedical Sciences - CDA
- Discipline *
- Immunology, Microbiology, Clinical Sciences
- +61 7 3138 6195
- +61 7 3138 6030
- View location details (QUT staff and student access only)
PhD (University of Otago)
Chlamydia, Mucosal Immunology, Reproductive Immunology, Sexually Transmitted Diseases, Vaccines
Research theme: Health
Research discipline: Cell and Molecular Biosciences
Development of vaccines to prevent chlamydial infections
Traditional vaccine approaches have been unsuccessful in preventing chlamydial infections. We have used novel DNA vaccination and bioinformatics approaches to identify protective chlamydial antigens that are conserved across several chlamydial species. Using combinations of these antigens we can reduce both the duration and magnitude of infection and reduce infection-associated inflammation that is the cause of infertility in animal models of chlamydial infection.
Development of needle-free immunisation methods
Novel approaches to vaccination including topical application to skin (transcutaneous immunisation), intranasal immunisation using drops or sprays and sublingual immunisation where vaccines are applied to the buccal epithelium are being investigated as an alternative to the traditional needle-based vaccines. In animal models these approaches can protect against Chlamydia and Helicobacter infections.
Affect of chronic chlamydial infections on inflammation and immunity
Chlamydia not only infects epithelial cells but can also infect immune cells such as dendritic cells and macrophages. Infection of these immune cells alters their function in a way that not only allows the Chlamydia to persist in the host but also increases the pro-inflammatory immune responses that cause conditions such as asthma.