Personal details

Name
Adjunct Associate Professor John Bartley
Position(s)
Adjunct Associate Professor
Science and Engineering Faculty,
Chemistry, Physics, Mechanical Engineering,
Nanotechnology and Molecular Science
Discipline *
Analytical Chemistry, Macromolecular and Materials Chemistry, Environmental Science and Management
Phone
+61 7 3138 2266
Fax
+61 7 3138 1804
Email
Location
View location details (QUT staff and student access only)
Identifiers and profiles
ORCID iD
Qualifications

PhD (University of Auckland), MSc (Hons) (University of Auckland), MSc (University of Auckland), BSc (University of Auckland)

Keywords

Chromatography, Mass spectrometry, Natural products, Nuclear magnetic resonance spectroscopy, Organic chemistry, Volatile flavours

* Field of Research code, Australian and New Zealand Standard Research Classification (ANZSRC), 2008

Biography

Research theme: Environment, Food, Health
Research discipline: Chemistry
Research areas
Isolation of Biologically Active Natural Products: Indigenous plants reported to be of medicinal value are under examination to determine that structural nature of any active components Techniques used include HPLC and spectroscopic methods, particularly 2D NMR techniques. Collaboration with the Queensland Institute of Medical Research and with the Forest Research Institute in Dehra Dun, Northern India is involved.
Mode of Action of the Anti-tumour Drug Fotemustine: The drug Fotemustine, was intended for treatment of brain tumours but high toxicity limits its use to tumours located in limb tissue Preliminary studies suggest that the mode of action is unusual and we are attempting to understand this by examining the reaction with short synthetic oligonucleotides using mass spectrometry techniques.
Drug interaction with triplex DNA: The drug coralyne binds more strongly to triplex DNA than to duplex DNA. The intimate nature of this interaction is being studied by 2D NMR experiments and will provide essential clues for the design of better ligands with increased sequence specificity and increased relative affinity for triplexes compared to duplexes.

This information has been contributed by Adjunct Associate Professor John Bartley.

Teaching

Teaching discipline: Chemistry

This information has been contributed by Adjunct Associate Professor John Bartley.

Publications


For more publications by this staff member, visit QUT ePrints, the University's research repository.

Supervision