- Professor Colleen Nelson
Faculty of Health,
School - Biomedical Sciences
- IHBI Membership
Institute of Health Biomedical Innovation (IHBI),
IHBI Health Projects,
IHBI Biomedical Sciences - CDA
- Discipline *
- Genetics, Oncology and Carcinogenesis
- +61 7 3176 7443
- +61 7 3176 7440
- View location details (QUT staff and student access only)
- Identifiers and profiles
PhD (Australian National University)
- Professional memberships
Director, Movember Board
Director, Rick Hansen Institute Board
Active Member, American Association for Cancer Research
Member, Inaugural Research Advisory Council, Michael Smith Foundation for Health Research
Member, Endocrine Society, USA
Vice-Chair, Scientific and Medical Advisory Board, Prostate Cancer Research Foundation of Canada
Regular Member, American Society for Biochemistry and Molecular Biology
Member, Endocrine Society, USA
Member Endocrine Society of Australia
Corporate Member, Queensland Clinical Trials Network
International Strategic Advisor, Prostate Cancer Canada
Member, American Society of Clinical Oncology
Scientific Advisory Board: Inphogene Bioinformatics
International Council of Advisors, Gerson Lehrman Group
Scientific Advisory Board: Molecular Templates
Scientific Advisory Board: OncoGenex
Advisor: World Congress on Microarray Technology
Queensland Government North American Partnerships
Queensland Government Precinct Development
Queensland Government, Developing Smarter Communities
Task Force, Queensland Biotech
Advisor, TRX10/ Queensland Clinical Trials Network
Canadian Australian Chamber of Commerce
Lifesciences and Biotech Queensland
Movember- Global Initiatives
Service to Hospitals
Department of Surgery Head Selection Committee, University of British Columbia and Vancouver General Hospital
Rick Hansen Institute, iCORD, Strategic Planning Committee for Spinal Cord Research, UBC, VGH
Professor Colleen Nelson is the Founder and Executive Director of the Australian Prostate Cancer Research Centre – Queensland (APCRC-Q) and Chair of Prostate Cancer Research at Queensland University of Technology (QUT). The Centre, based at the Translational Research Institute and the Princess Alexandra Hospital, spans the spectrum of discovery of new therapeutic targets and their preclinical and clinical development.
Prof Nelson’s expertise is in translational prostate cancer research, specifically in identification of potential therapeutic targets, their in vitro and in vivo validation, clinical validation through molecular pathology approaches, and their translation into potential clinical application. These outcomes are derived from her expertise in high throughput applications in microarray gene expression, gene regulation, animal models, prostate cancer, steroid hormones, molecular endocrinology, and targeted therapeutics.
Prof Nelson has long studied androgen action and the effects of androgen deprivation and progression to castrate resistant prostate cancer. Her laboratory made the seminal discovery that castrate resistant prostate tumours can synthesize their own androgens de novo from cholesterol. Recently, these findings have been extended to investigate the inter-relationships of androgen synthesis, prostate cancer progression, and metabolic syndrome.
Prof Nelson is also Director of the Australian-Canadian Prostate Cancer Research Alliance, an initiative developed to coordinate national and international network interactions of over 280 prostate cancer scientists and clinicians in Australia and Canada. The Alliance facilitates access to state-of-the-art infrastructure and clinical trials and assists in the translation of a wide range of discoveries in both countries. Since arriving in Australia in 2007, Prof Nelson has been awarded more than $29 million in research grants, including the prestigious Queensland Government Smart Futures Premier’s Fellowship in 2009.
Prof Nelson is Chair of the Translational Research Institute (TRI) Research Committee and a member of the TRI Caucus. She has also been appointed the Prostate Cancer Stream Leader within Diamantina Health Partners’ Comprehensive Cancer Centre.
Prior to her appointment in Australia, Prof Nelson was a founding scientist of the Vancouver Prostate Centre, a National Centre of Excellence in Research and Commercialization. Over the past decade she has worked in close collaboration with Dr Martin Gleave, Director of the Vancouver Prostate Centre. During that period, Prof Nelson was awarded research grants in excess of $100 million from most of the key biomedical funding agencies and industry in North America for peer-reviewed operating funds and establishment of state-of-the-art research facilities.
Intellectual property from Prof Nelson’s research has been licensed from University of British Columbia to OncoGenex Pharmaceuticals, a Vancouver-based biotechnology company. The lead agents are now in Phase II and Phase III clinical trials in North America. Prof Nelson has been on a number of Strategic and Scientific Advisory Boards and was the inaugural Director of the Microarray Platform for Genome Canada from 2000 to 2009.
In 2010, Prof Nelson was appointed to the Movember Foundation’s Board of Directors and serves as the Chair of Movember’s Global Scientific Committee. This committee leads Movember’s Global Action Plan initiative to accelerate key outcomes in prostate cancer research by facilitating global research collaboration projects.
Prof Nelson has been the Chair of the Canadian Prostate Cancer Research Initiative and now serves as an International Strategic Advisor for Prostate Cancer Canada. Since arriving in Australia, she has joined the Scientific Advisory Committee of the Australia New Zealand Urogenital Prostate Clinical Trials Group and chairs the Correlative and Translational Research Subcommittee.
Prof Nelson works closely with the Prostate Cancer Foundation of Australia. She has been a co-organiser of their international conferences and assists in their fund raising activities. She is passionate about prostate cancer advocacy and regularly disseminates information to community organisations, including prostate cancer support groups.
Prof Nelson has played a key role in helping to establish the first multi-disciplinary team (MDT) clinic for advanced prostate cancer in Australia – the linked MDT Prostate Cancer Trials Unit.
- Gunter J, Sarkar P, Lubik A, Nelson C, (2013) New players for advanced prostate cancer and the rationalisation of insulin-sensitising medication, International Journal of Cell Biology p1-13
- Sieh S, Taubenberger A, Rizzi S, Sadowski M, Lehman M, Rockstroh A, An J, Clements J, Nelson C, Hutmacher D, (2012) Phenotypic characterization of prostate cancer LNCaP cells cultured within a bioengineered microenvironment, PLoS One p1-16
- Gunter J, Lubik A, Mckenzie I, Pollak M, Nelson C, (2012) The interactions between insulin and androgens in progression to castrate-resistant prostate cancer, Advances in Urology p1-11
- Wang Q, Bailey C, Ng C, Tiffen J, Thoeng A, Minhas V, Lehman M, Hendy S, Buchanan G, Nelson C, Rasko J, Holst J, (2011) Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression, Cancer Research p7525-7536
- Lubik A, Gunter J, Hendy S, Locke J, Adomat H, Thompson V, Herington A, Gleave M, Pollak M, Nelson C, (2011) Insulin increases de novo steroidogenesis in prostate cancer cells, Cancer Research p5754-5764
- Locke J, Guns E, Lubik A, Adomat H, Hendy S, Wood C, Ettinger S, Gleave M, Nelson C, (2008) Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer, Cancer Research p6407-6415
- Mulholland D, Dedhar S, Wu H, Nelson C, (2006) PTEN and GSK beta : key regulators of progression to androgen-independent prostate cancer, Oncogene p329-337
- Thompson V, Morris T, Cochrane D, Cavanagh J, Wafa L, Hamilton T, Wang S, Fazli L, Gleave M, Nelson C, (2006) Relaxin becomes upregulated during prostate cancer progression to androgen independence and is negatively regulated by androgens, The Prostate p1698-1709
- Mulholland D, Dedhar S, Coetzee G, Nelson C, (2005) Interaction of nuclear receptors with Wnt/beta-Catenin/Tcf Signaling Axis: Wnt you like to know?, Endocrine Reviews p898-915
- Ettinger S, Sobel R, Whitmore T, Akbari M, Bradley D, Gleave M, Nelson C, (2004) Dysregulation of sterol response element-binding proteins and downstream effectors in prostate cancer during progression to androgen independence, Cancer Research p2212-2221
For more publications by this staff member, visit QUT ePrints, the University's research repository.