- Dr Brett Hollier
- Senior Research Fellow
Faculty of Health,
School - Biomedical Sciences,
Research - Biomedical Sciences
- IHBI Membership
Institute of Health Biomedical Innovation (IHBI),
IHBI Health Projects,
IHBI Biomedical Sciences - CDA
- Discipline *
- Biochemistry and Cell Biology, Other Biological Sciences
- +61 7 3443 7242
- +61 7 3176 7440
- View location details (QUT staff and student access only)
- Identifiers and profiles
PhD (Queensland University of Technology)
- Professional memberships
Australia-Canada Prostate Cancer Research Alliance
Metastasis Research Society
Epithelial-Mesenchymal Transition International Association (TEMITA)
The IGF (insulin-like growth factors) Society
Australian Society for Medical Research (ASMR)
Cancer, EMT, IGF, Metastasis, Stem cell
Dr Brett Hollier is an early career researcher investigating the mechanisms that mediate cancer metastasis. In particular, his research focuses on the Insulin-like Growth Factor (IGF) family and the epithelial-to-mesenchymal transition (EMT) program. Dr Hollier’s research focus is to better define the EMT program operating in cancer and its relevance to metastasis in order to identify novel biomarkers and therapeutic targets of EMT to better prognosticate and treat aggressive forms of cancer.
Dr Hollier was awarded a PhD in April 2008, in which he described for the first time the critical signalling events and transcriptional networks responsible for cancer cell migration induced by novel growth factor complexes. He conducted postdoctoral training at the M.D. Anderson Cancer Center (Houston, TX, USA) investigating the role of embryonic transcription factors in EMT, cancer stem cells and metastasis. During this 2 year training he was awarded a Susan G Komen for the Cure® Foundation Postdoctoral Fellowship, which resulted in 6 peer reviewed articles in high impact international journals, 1 book chapter and 1 provisional patent application.
He returned to Australia in late 2010 where he initiated an independent research laboratory at QUT. In 2012, he joined the APCRC-Q where he leads the Invasion and Metastasis laboratory. To date he has published 20 peer reviewed articles, including 15 original journal articles, 2 invited reviews, 1 invited commentary and 2 book chapters. He is an author on a further 8 manuscripts currently in final preparation or under review (4 as senior author). He is also an inventor on 3 patent applications and has held supervisory responsibilities for 2 postdoctoral researchers, 10 PhD students (4 Primary and 6 Associate) and 2 International exchange students.
Dr Hollier currently holds a 3 year QLD Smart Futures Fund Fellowship (2012-2015) to design smarter targeted therapies for cancer progression and is excited about the future opportunities to extend his research in these fields. In recognition of his research and his rapidly emerging national and international profile in the fields of Insulin-like growth factor (IGF) biology and mechanisms of cancer metastasis, particularly the EMT program, he has been invited and presented his findings at both national and international conferences as well as external research institutes.
For publications by this staff member, visit QUT ePrints, the University's research repository.
Completed supervisions (Doctorate)
- Characterizing the Role of Insulin Signalling in Advanced Prostate Cancer (2017)
- Investigating the Role of the Epithelial-Mesenchymal Plasticity in Prostate Cancer (2017)
- Towards the Development of Novel Bispecific Antibodies to Inhibit Key Cell Surface Receptors Integral for the Growth and Migration of Tumour Cells (2016)
- Identifying the Molecular Mediators of VN and the IGF: VN Complex-Stimulated Breast Cancer Cell Survival (2015)
- In Vitro Functional Characterisation of IGF-I:VN-induced Breast Cancer Progression (2013)
- Prognostic Significance of IGF and ECM Induced Signalling Proteins in Breast Cancer Patients (2012)