Personal details

Name
Emeritus Professor Adrian Herington
Position(s)
Adjunct Professor
Faculty of Health,
Faculty - Health
Emeritus Professor
Administrative Services,
Human Resources Department,
HR Client Services
Discipline *
Biochemistry and Cell Biology, Clinical Sciences, Oncology and Carcinogenesis
Phone
+61 417 074 038
Email
Location
View location details (QUT staff and student access only)
Qualifications

Ph.d (Monash University), B.Sc (Hons) (Monash University)

Professional memberships
and associations
  • Medical Advisory Board, Sylvia & Charles Viertel Charitable Foundation
  • Endocrine Society (USA)
  • Queensland Selection Panel, Australia-America Fulbright Fellowships
  • International Growth Hormone/IGF Research Society
  • International Proteolysis Society
  • Endocrine Society of Australia
  • Australasian Society for Biochemistry & Molecular Biology
  • Australian Society for Medical Research
Keywords

Endocrinology, Ephs and Ephrins, Ghrelin, Growth Factors, Growth Hormone, Hormone Receptors, Insulin-like Growth Factors, Prostate Cancer

* Field of Research code, Australian and New Zealand Standard Research Classification (ANZSRC), 2008

Biography

Research theme: Health Research discipline: Cell and Molecular Biosciences Research program:Hormone Dependent Cancer
Research areas

  • The expression, regulation and function of the growth factor ghrelin, its receptor and a novel overexpressed ghrelin antisense gene,  in hormone dependent cancer.
  • Identification and functional studies of a novel ghrelin antisense gene overexpressed in breast and prostate cancer.
  • The expression, regulation and function of the receptor tyrosine kinase EphB4 in hormone dependent cancers of the breast and prostate.

The above projects are the main focus of teams led by Prof Lisa Chopin Dr Sally Stephenson and Professor Herington. Profs Chopin and Herington were the first to identify ghrelin as an autocrine/paracrine growth factor for the hormone-dependent breast and prostate cancers. Ghrelin is a small peptide with multiple other roles including growth hormone release, appetite regulation, energy balance and immune regulation. We have identified several variants of the preproghrelin gene and the ghrelin receptor gene that show potential as biomarkers and/or therapeutic targets for breast and prostate cancer. Current studies are aimed at understanding the mechanisms underlying the tumour-related functions of the ghrelin axis.
EphB4 is a tyrosine kinase-linked receptor for members of the ephrin family of ligands. Together these proteins regulate cancer cell adhesion, motility, angiogenesis and metastasis. As potentially important therapeutic targets, this project aims to explore the expression, function and mechanisms/signalling pathways underlying EphB4-ephrin action
Areas of expertise

  • Hormone–Dependent Cancer
  • Growth Hormone Receptors / Action
  • Ghrelin
  • Insulin–Like Growth Factors

Past & Current grants

  • 2004-2006: NHMRC: Regulation and functional roles of ADAM10 in prostate cancer
  • 2005-2006: Queensland Cancer Fund: Heterodimerisation of the GHSR and cross–talk with the MAPK (mitogen–activated kinase) signalling pathway in prostate cancer
  • 2006-2007: Queensland Cancer Fund: The ghrelin axis and an exon 3 deleted ghrelin variant in breast cancer.
  • 2007-2008: Cancer Council Queensland: The opposing roles of a novel preproghrelin isoform and obestatin, a preproghrelin-derived hormone,  in prostate cancer
  • 2009-2010 Cancer Council Queensland: Novel natural antisense ghrelin mRNA transcripts and their role in breast and prostate cancer
  • 2011-2013: NHMRC: The function of the natural antisense ghrelin receptor gene (GHSROS) in cancer
  • 2014-2016: NHMRC: The ghrelin axis as a target for prostate cancer therapy
  • 2014-2016: ARC Discovery:

Selected research projects

  • The expression, regulation and function of the growth factor ghrelin and its receptor in hormone dependent cancer.
  • Identification, structural and functional studies of novel ghrelin receptors.
  • Expression, localization, regulation and functional consequences of EphB4 receptor tyrosine kinase in prostate and breast cancers.

Curriculum vitae, please download Adrian Herington´s CV (PDF 27kb) Further expertise and media contact

This information has been contributed by Emeritus Professor Adrian Herington.

Teaching

Teaching discipline: Cell & Molecular Biosciences
Teaching areas

  • Hormone Receptors and Signalling
This information has been contributed by Emeritus Professor Adrian Herington.

Publications


For more publications by this staff member, visit QUT ePrints, the University's research repository.

Supervision