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Associate Professor Dale Nyholt

Faculty of Health,
School - Biomedical Sciences

Personal

Name
Associate Professor Dale Nyholt
Position(s)
Associate Professor
Faculty of Health,
School - Biomedical Sciences
IHBI Membership
Institute of Health Biomedical Innovation (IHBI),
IHBI Health Projects,
IHBI Biomedical Sciences - CDA
Discipline *
Genetics, Statistics, Neurosciences
Phone
+61 7 3138 0067
Fax
+61 7 3138 6030
Email
Location
View location details (QUT staff and student access only)
Identifiers and profiles
Twitter LinkedIn
Qualifications

Ph.D Health Sciences (Griffith University)

Professional memberships
and associations

Head, Statistical and Genomic Epidemiology Laboratory (SGEL), Molecular Medicine Program Leader, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology (QUT).

View my Google Scholar webpage ; ResearcherID webpage ; current PubMed entries ; SGEL website.

** Prospective PhD students ** Please check out some of our current project and research opportunities. For more information about enrolling, please visit the QUT student Gateway.

If you already have a scholarship please contact us now about submitting an application to do your PhD with us!

PhD Scholarship opportunities: Applications for the QUT annual PhD scholarship round (QUT Postgraduate Research Awards (QUTPRA) closed at 11:59 PM on 30 September 2017. Interested students should, therefore, consider applying in next year’s Australia Awards–Endeavour Scholarships round (closing 30 June 2018) and QUT QUTPRA/RTPSI round (closing Sept 30 2018), and familiarise yourself with the application process and requirements (especially eligibility) outlined in the step-by-step details for applying for a PhD and research degree at https://www.qut.edu.au/study/applying/phd-and-research-degree-applications.

Keywords

Human Genetics, Medical Genetics, Neurogenetics, Genomics, Pharmacogenomics, Omics, Statistical Genetics, Biostatistics, Bioinformatics (both Analysis & Software Development), Computational Biology, Gene Expression, mRNA, eQTL, DNA Methylation, meQTL, Epigenetics, Metabolomics, Serum Metabolites, Sex Steroid Hormones, Menstruation, Glucose, Thyroid, Genetic Epidemiology, Epidemiology, Genes, Environment, Genetics of Migraine, Genetics of Depression, Genetics of Endometriosis, Genetics of Comorbid Disease, Comorbitity, Mental Health, Vascular Dysfunction, Quantitative Genetics (including Disease and Trait Mapping Genetics), Gene-Environment Interaction (GxE), Trigger Factors, Triggers, Baldness, Hair Loss, Motion Sickness, Obesity (BMI), Pain, Reproduction, Telomere Length, Twinning, Twins.

* Field of Research code, Australian and New Zealand Standard Research Classification (ANZSRC), 2008

Biography

I am a Human Geneticist expert in the statistical analysis of common complex traits. My expertise spans statistical genetic and genomic analysis, epidemiology, bioinformatics and biostatistics.

My Statistical and Genomic Epidemiology Laboratory (SGEL) studies the role of genetics in the development and mechanism of human traits, with particular emphasis on migraine, with the specific goal of identifying genetic risk factors and detecting common genetic links with other disorders, including depression and endometriosis.

The identification of such causal genetic factors and how they interact with environment exposures will provide a deeper understanding of the aetiology of migraine and our ability to prevent and treat attacks, and facilitate the discovery of novel pathways and thus identify new targets for drug therapy.

SGEL also develops novel statistical bioinformatics programs used by researchers worldwide.

** Prospective PhD students ** Please check out some of our current project and research opportunities. For more information about enrolling, please visit the QUT student Gateway.

All three of my recent QUT PhD students have obtained external (one international) postdoctoral positions!

Detailed Research Excellence

I am a world leader in genetic epidemiology. I have a career total of 192 publications. Since 2012, I have published 92 papers. I have managed, designed, and/or performed analyses and supplied interpretation for all my papers.

My career and 2012+ Google Scholar citations are 22907 and 17718; generating h-index values of 65 and 51, respectively. Over 90% of my papers are ranked in the top 25% (Q1) of their category by the SCImago Journal Rank indicator; over 50% are ranked in the top 5%. My publications clearly demonstrate my capacity to both lead and be part of teams that produce high impact research.

I have a career total of AU$21M in competitive funding as Chief Investigator (CI); holding 16 (64%) of my 25 grants as CIA. The primary funding bodies include the ARC, European Union, NHMRC, and USA NIH.

I have been a Peer Review Panel member for NHMRC 4 times. I have also been an NHMRC External Assessor 11 times and an external assessor for the Italian Telethon Foundation (2014), UK MRC (2014 and 2016), and Wellcome Trust (2010) international funding bodies.

Detailed Discipline Expertise

I am a Human Geneticist expert in statistical analysis. My expertise spans statistical genetic/genomic analysis, epidemiology, bioinformatics and biostatistics. I research the role of genetic and environmental factors in disease. I also develop novel bioinformatics programs used by researchers worldwide.

In the past 10 years, I have supervised 17 PhD students, 1 Masters student and 5 Postdocs (within mathematical, biological and psychiatric departments) and I currently supervise 2 PhD students and mentor 2 postdocs. I have been a PhD Thesis Examiner for Australian and International universities.

My past and ongoing national and international collaborations are extensive and I have a proven track record of leadership and performing high quality impactful research.

Since 2007, I have reviewed over 95 manuscripts for the following 23 internationally-recognised scientific journals: Genes, Cephalalgia, Human Reproduction, American Journal of Human Genetics, Twin Research and Human Genetics, Nature Communications, Molecular Psychiatry, European Journal of Human Genetics, Bioinformatics, Gynecologic and Obstetric Investigation, The Lancet Neurology, JAMA Psychiatry, Journal of Autism and Developmental Disorders, Headache, PLoS Genetics, Headache Research and Treatment, Molecular Human Reproduction, Expert Review of Neurotherapeutics, Neuropsychiatric Genetics, Human Genetics, Genetic Epidemiology, Biological Psychiatry, and Human Molecular Genetics.

Detailed Professional and Academic Standing

I am the only statistical geneticist and Australian PI on the large €6M EU project ‘Mechanisms and Treatment of Migraine and its Chronification’ (Acronym: EUROHEADPAIN), for which I directed the keystone ‘Genetic biomarkers and molecular pathways for migraine’ work package.

Since 2012 I have received: 11 conference presentation invitations (8 international; 3 keynote/plenary); 7 (2 international) conference presentation invitations selected from abstract; and 5 (2 international) invitations as Session Chair at conferences.

From May 2015 to May 2016, I was awarded a prestigious Visiting Professors Programme award by The Royal Netherlands Academy of Arts and Sciences, to “enable outstanding foreign researchers to spend up to 3 months working in the Netherlands”.

In the past 2 years, I was invited to write reviews for premier neurological journals Cephalalgia, Curr Opin Neurol, and Nat Rev Neurol.

I have served on the Editorial Board of the International Q1 peer-reviewed journal Genes since 2010.

I am on and actively participate in numerous QUT Committees.

Detailed Interpersonal and Team Skills and Experience

As a leader of large national and international research programs, I have significant experience managing people and projects, and always to planned deadlines. I am a leading Principal Investigator (PI) in the International Headache Genetics (IHGC) and International Endometriosis (IEC), and Twinning Genetics (TGC) Consortiums.

All these roles require demonstration of my strong forward planning and advocacy skills.

At QUT, I was recently appointed the Molecular Medicine Program Leader—responsible for developing and improving medical research.

My ability and willingness to lead is also demonstrated by my position as Chair of the QIMR Berghofer Information Technology Committee (2008-2011). My organised, collaborative and mentoring reputation is reflected in Conference Committee Membership invitations for two large national conferences and my membership of the QIMR Berghofer Mentoring Committee from 2010 until my move to QUT in Feb 2015.

This information has been contributed by Associate Professor Dale Nyholt.

Publications


For more publications by this staff member, visit QUT ePrints, the University's research repository.

Awards

Awards and recognition

Type
Assessor, Examiner or Supervisor Role
Reference year
2017
Details
In the past 10 years, I have supervised 17 PhD students (4 Primary Supervisor, 6 Co-Supervisor, 7 Mentor), 1 Masters student (1 Primary Supervisor) and 5 Postdocs (4 Primary Supervisor, 1 Mentor).
Type
Editorial Role for an Academic Journal
Reference year
2017
Details
Editorial Board Member for the journal 'Genes' since 16 Mar 2010.
Type
Funding Award
Reference year
2017
Details
I have a career total of AU$21M in competitive funding as Chief Investigator (CI); holding 16 (64%) of my 25 grants as CIA. The primary funding bodies include the NHMRC, European Union (EU), and NIH.
Type
International Collaboration
Reference year
2017
Details
I have, and continue to, conceive and lead large multidisciplinary collaborations; with a particular focus on migraine and co-occurring disorders. I am a founding Principal Investigator (PI) in the International Headache Genetics Consortium (IHGC), International EndoGene Consortium (IEC), and Twinning Genetics Consortium (TGC). I am also an active member of the Psychiatric Genomics Consortium (PGC) and major depressive disorder (MDD) Workgroup (PGC-MDD). I am the only Australian PI on the 6 million EU FP7 project (2014-2017) 'Mechanisms and Treatment of Migraine and its Chronification' (Acronym: EUROHEADPAIN), for which I direct the keystone 'Genetic biomarkers and molecular pathways for migraine' work package.
Type
Keynote Speaker/Expert Panel Member/Invited Speaker for a Conference
Reference year
2017
Details
Since 2007, I have been an Invited Speaker 10 times (6 int'l), Keynote Speaker 4 times (4 int'l), and Plenary Speaker once for Conferences.
Type
Reviewer for an Academic Journal
Reference year
2017
Details
Since 2007, I have reviewed over 95 manuscripts for the following 23 internationally-recognised scientific journals: Genes, Cephalalgia, Human Reproduction, American Journal of Human Genetics, Twin Research and Human Genetics, Nature Communications, Molecular Psychiatry, European Journal of Human Genetics, Bioinformatics, Gynecologic and Obstetric Investigation, The Lancet Neurology, JAMA Psychiatry, Journal of Autism and Developmental Disorders, Headache, PLoS Genetics, Headache Research and Treatment, Molecular Human Reproduction, Expert Review of Neurotherapeutics, Neuropsychiatric Genetics, Human Genetics, Genetic Epidemiology, Biological Psychiatry, and Human Molecular Genetics.
Type
Membership of Review Panels on Prestigious Grant Applications
Reference year
2017
Details
Since 2007 I have been an NHMRC Project Grant External Assessor 11 times and Peer Review Panel member 4 times.
Type
Membership of Review Panels on Prestigious Grant Applications
Reference year
2016
Details
I have been a project grant assessor for the Italian Telethon Foundation (2014), UK MRC (2014, 2016), and Wellcome Trust (2010) international funding bodies. I was also a Wellcome Trust Fellowship Assessor in 2011.
Type
Recipient of a Nationally Competitive Research Fellowship
Reference year
2015
Details
Recipient of an NHMRC Senior Research Fellowship (Level B). Starting 1 Jan 2010, Ending 31 Dec 2015. NB, Honorary status between 1 Feb 2010 and 31 Jan 2014.
Type
Recipient of a Nationally Competitive Research Fellowship
Reference year
2014
Details
Recipient of ARC Future Fellowship (Level 1). Starting 1 Feb 2010, Ending 31 Jan 2014.

Research projects

Grants and projects (Category 1: Australian Competitive Grants only)

Title
Genetic biomarkers and molecular pathways for migraine
Primary fund type
CAT 1 - Australian Competitive Grant
Project ID
1075175
Start year
2014
Keywords
Migraine; Neurogenetics; Neurological Disorders; Genetic Risk Factors; Pain Mechanisms
Title
Elucidating the Molecular Mechanisms Underlying Migraine and Endometriosis via Genetic Dissection
Primary fund type
CAT 1 - Australian Competitive Grant
Project ID
613674
Start year
2010
Keywords
Migraine; Endometriosis; Genetic Epidemiology; Genetic Disease; Genetic Predisposition
Title
Identification of novel common genetic risk factors for endometriosis
Primary fund type
CAT 1 - Australian Competitive Grant
Project ID
1050208
Start year
2013
Keywords
Endometriosis; Genetic Risk Factors; Genetic Mapping; Fertility; Reproductive Health; Reproductive Disorders
Title
Development and Application of Novel Bioinformatics Approaches to Identify Pathogenetic Mechanisms Underlying Migraine
Primary fund type
CAT 1 - Australian Competitive Grant
Project ID
1091816
Start year
2015
Keywords
Brain Disorders; Bioinformatics; Migraine; Systems Biology; Single Nucleotide Polymorphism (SNP)
Title
Clinical Trials - Genetic Variants underlying X-linked familial migraine
Primary fund type
CAT 1 - Australian Competitive Grant
Project ID
1058808
Start year
2014
Keywords
Migraine; Molecular Genetics; Genetic Analysis; Genetic Linkage; Genetic Susceptibility

Supervision

  • I am a Level 3 Higher Degree Research (HDR) Mentoring Supervisor. I have supervised a total of 17 PhD students (4 as Primary Supervisor, 6 as Co-Supervisor and 7 as Mentor) and 1 Masters student (as Primary Supervisor). All these students successfully completed their course in a timely manner.

  • All three of my recent QUT PhD students obtained external (including one in Toronto Canada) postdoctoral positions either before or directly after their graduation. My earlier PhD students continue to be employed as a Senior Lecturer and Postdoctoral Research Associates/Fellows in Australia and overseas (Europe and USA). In other words, a PhD with us will provide you with excellent training and mentoring, and real opportunities to further your research career.

  • Most importantly – because our Lab has access to existing (/impending) world-class datasets and resources, commencing students can begin their research almost immediately. That is, you will essentially already have all necessary resources at your fingertips so you won’t have to worry about delays from wet-lab experiments, and/or the output from others to successfully complete your research.

  • Please check out some of our Lab’s current project and research opportunities. For more information about enrolling, please visit the QUT student Gateway and the QUT PhDs and research degrees website.

Current supervisions

  • Common Comorbid Complaints in Edometriosis Patients
    PhD, Principal Supervisor
    Other supervisors: Professor Lyn Griffiths

Completed supervisions (Doctorate)