Personal
- Name
- Dr Konstantin Momot
- Position(s)
- Senior Lecturer in Experimental Physics
Science and Engineering Faculty,
Chemistry, Physics, Mechanical Engineering,
Nanotechnology and Molecular Science - IHBI Member
Institute of Health Biomedical Innovation (IHBI),
IHBI Science and Engineering Projects,
IHBI Chem Physics Mech Engineering - Medical Devic - Discipline *
- Other Physical Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics
- Phone
- +61 7 3138 1173
- k.momot@qut.edu.au
- Location
- View location details (QUT staff and student access only)
- Qualifications
-
PhD (Arizona State University)
- Professional memberships
and associations - RACI
- ANZMAG
- Australian Society for Biophysics
- Keywords
-
biomaterials, drug delivery vehicles, Magnetic Resonance Imaging (MRI), Molecular transport and diffusion, NMR spectroscopy of tissues, Nuclear Magnetic Resonance (NMR)
Biography
Research theme: Health
Research discipline: Physics
Research program: Medical Physics
Research areas
Molecular dynamics of hydrated cartilage biopolymers: The aim of this project is to study molecular dynamics of hydrated collagen and proteoglycans – biopolymers forming the molecular scaffold of cartilage. The objective is to investigate the effect of aligned collagen fibres on NMR properties of tissue water, and to use that information for interpretation of cartilage MR images.
NMR spectroscopy and MR microimaging of cartilage: This project involves the development of state-of-the-art techniques of cartilage microimaging: diffusion-tensor imaging, MRI mechanical-load consolidometry, and quantitative relaxation-weighted imaging. The aim is to characterise the macromolecular structure of the tissue scaffold; study its response to mechanical load and enzymatic degradation; and to identify reliable MRI signatures of early osteoarthritis.
NMR and computational studies of bicontinuous cubic phases: BCPs are thermodynamically stable lipids/water systems used to model the biophysics of lipid bilayers. We use Monte Carlo simulations and NMR spectroscopy to investigate the relationship between microstructure, molecular mobility, and molecular transport properties of BCPs. The aim is to develop an in vitro permeability model of the lipid bilayer.
Areas of expertise
- Magnetic resonance spectroscopy and imaging
- Molecular transport and diffusion
- Lipid bilayer systems
- Numerical simulations of molecular dynamics.
Current grants
- Mobility of water in cartilage as a probe of molecular structure and function – ARC Discovery
Selected research projects
- Magnetic resonance imaging of cartilage
- Molecular dynamics and Monte Carlo simulations of hydrated cartilage biopolymers.
Teaching
Teaching discipline: Physics
Teaching areas
- Statistical Physics and Statistical Mechanics
- Advanced Quantum Mechanics
- General Physics
- Magnetic Resonance spectroscopy and imaging
Publications
- Momot K, Pope JM, Wellard RM, (2011) Digital processing of diffusion-tensor images of avascular tissues, Medical Image Processing. Techniques and Applications p341-371
- Momot K, (2011) Diffusion tensor of water in model articular cartilage, European Biophysics Journal p81-91
- Momot K, Pope JM, Wellard RM, (2010) Anisotropy of spin relaxation of water protons in cartilage and tendon, NMR in Biomedicine p313-324
- De Visser SK, Bowden JC, Wentrup-Byrne E, Rintoul L, Bostrom T, Pope JM, Momot K, (2008) Anisotropy of collagen fibre alignment in bovine cartilage: comparison of polarised light microscopy and spatially resolved diffusion-tensor measurements1, Osteoarthritis and Cartilage p689-697
- Momot K, Kuchel PW, (2006) PFG NMR Diffusion Experiments for Complex Systems, Concepts in Magnetic Resonance. Part A p249-269
- Momot K, Kuchel PW, (2005) Convection-compensating diffusion experiments with phase-sensitive double-quantum filtering, Journal of Magnetic Resonance p229-236
- Momot K, Kuchel PW, (2004) Convection-compensating PGSE experiment incorporating excitation-sculpting water suppression (CONVEX), Journal of Magnetic Resonance p92-101
- Momot K, Kuchel PW, Chapman BE, Deo P, Whittaker D, (2003) NMR study of the association of propofol with nonionic surfactants, Langmuir: the ACS journal of surfaces and colloids p2088-2095
- Momot K, Kuchel PW, (2003) Pulsed field gradient nuclear magnetic resonance as a tool for studying drug delivery systems, Concepts in Magnetic Resonance. Part A p51-64
- Momot K, Johnson CS, (2001) Nuclear Magnetic Resonance radiation damping in inhomogeneous radio frequency fields: the toroid cavity detector, Journal of Chemical Physics p3992-4002
For more publications by this staff member, visit QUT ePrints, the University's research repository.
Awards
Awards and recognition
- Type
- Keynote Speaker/Expert Panel Member/Invited Speaker for a Conference
- Reference year
- 2010
- Details
- Invited speaker at the PacifiChem 2010 Conference, Honolulu, USA - bi-annual conference of the chemical societies of the Pacific Rim
- Type
- Membership of Learned Societies
- Reference year
- 2006
- Details
- Society Treasurer, Australian and NZ Society for Magnetic Resonance
- Type
- Visiting Professorships/Fellowships
- Reference year
- 2006
- Details
- JSPS Visiting Research Fellow, Kyoto University
- Type
- Academic Honours, Prestigious Awards or Prizes
- Reference year
- 2000
- Details
- Humboldt Research Fellow
Research projects
Grants and projects (Category 1: Australian Competitive Grants only)
- Title
- Mobility of Water in Cartilage as a Probe of Molecular Structure and Function
- Primary fund type
- Australian Competitive Grants
- Project ID
- DP0880346
- Start year
- 2008
- Keywords
- Cartilage, Collagen and Proteoglycans, Osteoarthritis, Diffusion Tensor, Magnetic Resonance Imaging, Coarse Grained Simulations
