- Dr Eloise Dray
- Research Fellow
Faculty of Health,
School - Biomedical Sciences,
Research - Biomedical Sciences
- IHBI Membership
Institute of Health Biomedical Innovation (IHBI),
IHBI Health Projects,
IHBI Biomedical Sciences - CDA
- Discipline *
- Medical Biochemistry and Metabolomics, Medical Microbiology
- +61 7 3443 7342
- View location details (QUT staff and student access only)
PhD (University of Paris-Sud (University of Paris XI))
DNA Repair, Homologous Recombination, Breast Cancer, Metastasis, Biochemistry
Current Position. I was recently recruited by the Queensland University of Technology as a Research Fellow, and started my autonomous research group. I am the recipient of a Vice Chancellor Research Fellowship and a National Breast Cancer Foundation Early Career Fellowship. My laboratory is always looking for new talents to enrich the team. Undergraduate students, prospective PhD students and postdoctorate candidates are strongly encouraged to contact me to find out about opportunities available in the lab: email@example.com
2002-2006: PhD training. I received my Ph.D. degree in France, from the University Paris 11 where I studied the tumor suppressor BRCA2 in Arabidopsis thaliana. I applied a combination of genetics, cytology, cell biology, plant physiology and basic biochemistry to succeed in my research. I was able to establish a link between the breast cancer protein BRCA2 and the meiotic recombinase DMC1. This finding opened a totally new path in the international BRCA2-research field, and was published in the EMBO journal.
2006-2011: Postdoctoral training in Patrick Sung’s laboratory at Yale University, USA. During this time, I was extensively trained as a biochemist and rapidly became conversant in recombination protein biochemistry and enzymology. I developed and optimized powerful biochemical tools to analyze new human proteins involved in human disease (PALB2 is involved in breast cancer, pancreas cancer, leukemia and Fanconi anemia) through DNA repair. I deciphered the role of the then poorly understood RAD51AP1 protein. I was able to purify the PALB2 protein (a BRCA2 partner) and study it from a biochemical point of view, establishing its physical interaction with the recombinase RAD51.
Jan. 2012- Jan 2013: Associate Research Fellow “Biology of Triple Negative Breast Cancer” at The University of Queensland, in Melissa Brown’s Laboratory. In 2012, I joined Melissa Brown group at the University of Queensland, Brisbane, Australia, where I acquired new skills in gene expression analysis, and resumed my training in cell-based assays.
2002-2005: Teaching responsibilities. Total of 300 hours of microbiology (fundamental and applied to industry), genetics, and physiology to a very diverse audience (B.Sc. to Masters students). For this purpose, I designed my own lectures (about 200 hours of lectures and 100 hours of laboratory classes), under the tutelage of senior professors.
- Hansen JE, Chan G, Liu Y, Hegan DC, Dalal S, Dray E, Kwon Y, Xu Y, Xu X, Peterson-Roth E, Geiger E, Liu Y, Gera J, Sweasy JB, Sung P, Rockwell S, Nishimura RN, Weisbart RH, Glazer PM, (2012) Targeting cancer with a lupus autoantibody, Science Translational Medicine p1-8
- Dunlop M, Dray E, Zhao W, San Filippo J, Tsai M, Leung SG, Schild D, Wiese C, Sung P, (2012) Mechanistic insights into RAD51-associated protein 1 (RAD51AP1) action in homologous DNA repair, Journal of Biological Chemistry p12343-12347
- Islam M, Paquet N, Fox III D, Dray E, Zheng X, Klein H, Sung P, Wang W, (2012) A variant of the breast cancer type 2 susceptibility protein (BRC) repeat is essential for the RECQL5 helicase to interact with RAD51 recombinase for genome stabilization, Journal of Biological Chemistry p23808-23818
- Dray E, Dunlop M, Kauppi L, San Filippo J, Wiese C, Tsai M, Begovic S, Schild D, Jasin M, Keeney S, Sung P, (2011) Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1), Proceedings of the National Academy of Sciences of the United States of America p3560-3565
- Dunlop M, Dray E, Zhao W, Tsai M, Wiese C, Schild D, Sung P, (2011) RAD51-associated protein 1 (RAD51AP1) interacts with the meiotic recombinase DMC1 through a conserved motif, Journal of Biological Chemistry p37328-37334
- Dray E, Etchin J, Wiese C, Saro D, Williams GJ, Hammel M, Yu X, Galkin VE, Liu D, Tsai M, Sy SM, Schild D, Egelman E, Chen J, Sung P, (2010) Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2, Nature Structural and Molecular Biology p1255-1259
- Siaud N, Dubois E, Massot S, Richaud A, Dray E, Collier J, Doutriaux M, (2010) The SOS screen in Arabidopsis: A search for functions involved in DNA metabolism, DNA Repair p567-578
- Prakash R, Satory D, Dray E, Papusha A, Scheller J, Kramer W, Krejci L, Klein H, Haber JE, Sung P, Ira G, (2009) Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination, Genes and Development p67-79
- Dray E, Saro D, Sung P, (2008) Chromosome damage repair: strategies and complications in targeting the BRCA2-PALB2 axis for cancer therapy, Cellscience Reviews p249-254
- Wiese C, Dray E, Groesser T, San Filippo J, Shi I, Collins DW, Tsai M, Williams GJ, Rydberg B, Sung P, Schild D, (2007) Promotion of homologous recombination and genomic stability by RAD51AP1 via RAD51 recombinase enhancement, Molecular Cell p482-490