QUT - Academic profiles - Adjunct Professor Steven Bottle

Biography

Research theme: Health, Environment

Research discipline: Chemistry

Research program: Medical & Forensic Chemistry

Research areas:

Detecting Free Radicals and Reactive Oxygen Species Using Fluorescence.
The use of novel antioxidants to limit oxidative stress in Friedrich's Ataxia and Ataxia Telangiectasia.
Detecting cellular oxidative stress using Flow Cytometry and Confocal Microscopy.
Design and synthesis of new profluorescent additives for materials protection and lifetime prediction.

The group has developed world-leading expertise in the synthesis and application of nitroxide free radicals which has led to the preparation of novel antioxidant molecules of therapeutic value. These drug candidates have application in diseases such as Ataxia Telangiectasia and Friedrich's Ataxia as well as hypertension, inflammation and heart disease. The group has also developed considerable expertise in the use of fluorescence to detect levels of oxidative stress in biological systems, as well as monitor the degradation of materials through environmental exposure. Of particular interest has been the important discovery that fluorescence can be used to monitor free radical degradation in polymers and thereby predict a material's end of application lifetime. During 2007 the Bottle group began a collaboration with scientists and engineers from the Department of Defense to develop smart materials with application in the aeronautical industry, particularly the Joint Strike Fighter program.

+61 7 3138 1356

s.bottle@qut.edu.au

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Personal details

Positions

Adjunct Professor
Faculty of Science,
School of Chemistry & Physics

Keywords

Antioxidants (radical scavengers, stabilisers & additives), Fluorescence, Free Radicals, Free radicals in ageing, cancer & diseases, Materials degradation, Medicinal chemistry (development of antioxidant drugs), Nitroxides, Oxidation - active oxygen, Particulate Pollution, Polymers

Research field

Organic chemistry, Macromolecular and materials chemistry, Medicinal and biomolecular chemistry

Field of Research code, Australian and New Zealand Standard Research Classification (ANZSRC), 2020

Qualifications

PhD (Griffith University)
BSc(Hons) (University of Queensland)

Publications

QUT ePrints

For more publications by Steven, explore their research in QUT ePrints (our digital repository).

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2024

Marasinghege, C., Shi, C., Bottle, S., Bartley, J., Doherty, W. O. S. & Rackemann, D. W. (2024). One pot two-alkali clarification process to minimize sucrose degradation of clarified sugarcane juice during evaporation. Journal of Food Engineering, Article 112022, 374. https://eprints.qut.edu.au/247507
Soltau, C. P., Weir, N. E., Martyn, A. P. & Bottle, S. E. (2024). Synthesis of Antioxidant Steroids by Hybridisation with Nitroxides. Synthesis, 56(21), 3289–3296. https://eprints.qut.edu.au/252905

2023

Han, P., Mao, X., Jin, Y., Sarina, S., Jia, J., Waclawik, E. R., Du, A., Bottle, S. E., Zhao, J. C. & Zhu, H. Y. (2023). Plasmonic Silver-Nanoparticle-Catalysed Hydrogen Abstraction from the C(sp3)-H Bond of the Benzylic C_α atom for Cleavage of Alkyl Aryl Ether Bonds. Angewandte Chemie International Edition, Article e202215201, 62(4). https://eprints.qut.edu.au/238522
Tana, T., Han, P., Brock, A. J., Mao, X., Sarina, S., Waclawik, E. R., Du, A., Bottle, S. E. & Zhu, H. Y. (2023). Photocatalytic conversion of sugars to 5-hydroxymethylfurfural using aluminium(III) and fulvic acid. Nature Communications, Article 4609, 14. https://eprints.qut.edu.au/244227
Loomans, B. I., Bottle, S. E. & Blinco, J. P. (2023). Bipolar Isoindoline Nitroxide for Nonaqueous Symmetrical Redox Flow Battery. Batteries and Supercaps, Article e202200561, 6(6). https://eprints.qut.edu.au/245644
Rayner, C. L., Bottle, S. E., Martyn, A. P. & Barnett, N. L. (2023). Preserving Retinal Structure and Function with the Novel Nitroxide Antioxidant, DCTEIO. Neurochemical Research, 48(11), 3402–3419. https://eprints.qut.edu.au/246201

2022

Marasinghege, C., Broadfoot, R., Bottle, S., Bartley, J., Doherty, W. O. S. & Rackemann, D. W. (2022). Investigation on the effect of the heating surface temperature of 1st evaporator on sucrose loss and the degradation of sugarcane juice constituents. Journal of Food Engineering, Article 111074, 329. https://eprints.qut.edu.au/229945
Liu, X., Shi, Y., Jin, Y., Tana, T., Peiris, E., Zhang, X., Xu, F., Waclawik, E. R., Bottle, S. E., Zhu, H. & Sarina, S. (2022). Surface-Plasmon-Enhanced Transmetalation between Copper and Palladium Nanoparticle Catalyst. Angewandte Chemie - International Edition, Article e202203158, 61(24). https://eprints.qut.edu.au/230338
Han, P., Tang, C., Sarina, S., Waclawik, E. R., Du, A., Bottle, S. E., Fang, Y., Huang, Y., Li, K. & Zhu, H. Y. (2022). Wavelength-Specific Product Desorption as a Key to Raising Nitrile Yield of Primary Alcohol Ammoxidation over Illuminated Pd Nanoparticles. ACS Catalysis, 12(4), 2280–2289. https://eprints.qut.edu.au/230340
Soltau, C. P., Brown, Z. E., Brock, A. J., Martyn, A. P., Blinco, J. P., Miljevic, B., McMurtrie, J. C. & Bottle, S. E. (2022). Reactions of sulfoxides with reactive oxygen species to reveal the radical chemistry of pollution-derived particulate matter. Chemical Communications, 58(74), 10416–10419. https://eprints.qut.edu.au/237332

2021

Liu, Q., Chavhan, S., Zhang, H., Sun, H., Brock, A. J., Manzhos, S., Chen, Y., Feron, K., Bottle, S. E., McMurtrie, J. C., Jou, J. H., Chen, H. S., Nagar, M. R., Hu, W., Noh, Y. Y., Zhen, Y. & Sonar, P. (2021). Short alkyl chain engineering modulation on naphthalene flanked diketopyrrolopyrrole toward high-performance single crystal transistors and organic thin film displays. Advanced Electronic Materials, Article 2000804, 7(1). https://eprints.qut.edu.au/207076
Wu, X., Liu, Q., Surendran, A., Bottle, S. E., Sonar, P. & Leong, W. L. (2021). Enhancing the electrochemical doping efficiency in diketopyrrolopyrrole-based polymer for organic electrochemical transistors. Advanced Electronic Materials, Article 2000701, 7(1). https://eprints.qut.edu.au/207074
Turangan, N., Xu, Y., Spratt, H., Rintoul, L., Bottle, S. & MacLeod, J. (2021). Self-supporting covalent organic framework membranes synthesized through two different processes: Solvothermal annealing and solvent vapor annealing. Nanotechnology, Article 075604, 32(7). https://eprints.qut.edu.au/209102
Han, P., Tana, T., Sarina, S., Waclawik, E. R., Chen, C., Jia, J., Li, K., Fang, Y., Huang, Y., Doherty, W., Bottle, S. E., Zhao, J. & Zhu, H. Y. (2021). Plasmonic silver nanoparticles promoted sugar conversion to 5-hydroxymethylfurfural over catalysts of immobilised metal ions. Applied Catalysis B: Environmental, Article 120340, 296. https://eprints.qut.edu.au/211012
Liu, Q., Moghe, D., Sardar, G., Manzhos, S., Bottle, S. E., Kyaw, A. K. K., Kabra, D. & Sonar, P. (2021). Structural geometry variation of 1,4-naphthalene-based co-polymers to tune the device performance of pvk-host-based oleds. Polymers, Article 2914, 13(17). https://eprints.qut.edu.au/213542

A complete list of publications is available at: https://www.qut.edu.au/about/our-people/academic-profiles/s.bottle

Supervision

Supervision topics

Metal-free batteries

Adjunct ProfessorSteven Bottle