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Professor Kenneth Beagley

Faculty of Health,
School - Biomedical Sciences

Personal

Name
Professor Kenneth Beagley
Position(s)
Associate Director (QMIR-B)
Faculty of Health,
School - Biomedical Sciences
Professor of Immunology
Faculty of Health,
School - Biomedical Sciences
IHBI Membership
Institute of Health Biomedical Innovation (IHBI),
IHBI Health Projects,
IHBI Biomedical Sciences - CDA
Discipline *
Immunology, Microbiology, Clinical Sciences
Phone
+61 7 3138 6195
Fax
+61 7 3138 6030
Email
Location
View location details (QUT staff and student access only)
Qualifications

PhD (University of Otago)

Keywords

Chlamydia, Mucosal Immunology, Reproductive Immunology, Sexually Transmitted Diseases, Vaccines

* Field of Research code, Australian and New Zealand Standard Research Classification (ANZSRC), 2008

Biography

Research theme: Health

Research discipline: Cell and Molecular Biosciences

Research area

Development of vaccines to prevent chlamydial infections

Traditional vaccine approaches have been unsuccessful in preventing chlamydial infections. We have used novel DNA vaccination and bioinformatics approaches to identify protective chlamydial antigens that are conserved across several chlamydial species. Using combinations of these antigens we can reduce both the duration and magnitude of infection and reduce infection-associated inflammation that is the cause of infertility in animal models of chlamydial infection.

Development of needle-free immunisation methods

Novel approaches to vaccination including topical application to skin (transcutaneous immunisation), intranasal immunisation using drops or sprays and sublingual immunisation where vaccines are applied to the buccal epithelium are being investigated as an alternative to the traditional needle-based vaccines. In animal models these approaches can protect against Chlamydia and Helicobacter infections.

Affect of chronic chlamydial infections on inflammation and immunity

Chlamydia not only infects epithelial cells but can also infect immune cells such as dendritic cells and macrophages. Infection of these immune cells alters their function in a way that not only allows the Chlamydia to persist in the host but also increases the pro-inflammatory immune responses that cause conditions such as asthma.

This information has been contributed by Professor Kenneth Beagley.